The EXPOsOMICS project aims to develop a new approach to assess environmental exposures, primarily focusing on air pollution and water contaminants.
Using ‘omic’ techniques the collected exposure data can be linked to biochemical and molecular changes in our body. The results will help to improve our understanding on how these pollutants influence the risk of developing chronic diseases.
The exposome concept refers to the totality of environmental exposures from conception onwards, and is a novel approach to studying the role of the environment in human disease.
For more information please visit the EXPOsOMICS website.
Kings College London leads on air pollution monitoring and modeling in WP3 as well as leads WP6 and conduct analysis of protein adducts (adductomics).
The aim of the air pollution component in the project is to construct the short term and long term air pollution exposure estimates for adults and children via both personal and ambient measurements and modelling using novel and existing technologies.
Epidemiological studies traditionally assessed air pollution exposure based on data collected by outdoor monitoring stations at fixed locations. This exposure estimation method however does not take into account the micro-environmental conditions (e.g. indoor-outdoor exposure) and personal activity patters (i.e. traveling from-to work).
One of the advances of this project is to develop personal exposure models by using a mobile personal exposure monitoring (PEM) system.
|Name||Expertise||Role in the project|
|Professor Frank Kelly||Respiratory toxicology and physiology||WP3 participant Joint lead at Personal monitoring in short term studies task Lead Development of LUR models for OP measurements task|
|Professor David Phillips||Human biomonitoring and carcinogen activation||Lead of WP6|
|TBA||Modeller||Model development for PM oxidative potential|
|Layla Aithadj||Toxicologist||PM filter oxidative potential analysis|
|George Preston||Adductomics analysis||Adductomics analysis|
New research project to reveal health effects of environmental pollutants